Phenotype Image Detail

Image

Caption

Purkinje cells and cells surrounding blood vessels show increased levels of heme oxygenase (HO) in Atm^tm1Awb/Atm^tm1Awb mice . The yellow fluorescent signal shown in A and B is from anti-HO-1 staining in a wild-type (A) and Atm^tm1Awb/Atm^tm1Awb (B) mouse cerebellum at high magnification (x100) to show the significant increase in staining in the Purkinje cell layer. m Indicates the molecular layer, p and outline indicate the Purkinje cell layer, and g indicates the granular cell layer. Note the intense signal in the Purkinje cell soma of the mutant mouse brain in (B). The increased staining in the molecular layer is likely caused by HO in the dendritic arbors, as the spines are well demarcated by the intense staining (double arrows). The granular cell layer (g) staining is similar in the wild-type and mutant mice. C (wild type) and D (mutant) show the increase in bright orange signal from anti-Hmox2, which is prominent in cells surrounding the vasculature of the cerebral cortex in the mutant mouse (D). x40

Copyright

This image is from Barlow C, Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9915-9. Copyright 1999 National Academy of Sciences, U.S.A. J:57115

Associated Alleles

Symbol	Name
Atm^tm1Awb	ataxia telangiectasia mutated; targeted mutation 1, Anthony Wynshaw Boris

Associated Genotypes

Allelic Composition	Genetic Background
Atm^tm1Awb/Atm^tm1Awb	either: 129S6/SvEvTac-Atm^tm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss)