Phenotype Image Detail

Image

Caption

Shown are Purkinje cells (PC) from wild type (A) mouse where lysosomes are rarely encountered. In contrast, in the Atm^tm1Awb/Atm^tm1Awb PC shown, there are large clusters of lyosomes in the PC cytoplasm (B, arrows). Similar abnormalities could be seen outside the PC layer. (D) Clusters of lysosomes in the granular cell layer (G) of the homozygous mutant, which are not apparent in the wild type (C). E & F: Detail of the fine structure of the lysosomes in the homozygous mutant mouse brains. Somatic primary lysosomes are marked by arrows in E. Lipofuscin granules (complex, engorged lysosomes; arrowheads) are shown in F. Note the lack of ultrastructural defects even in the presence of the lysosomal proliferation. Abbreviations: n: neuropil; N: nucleus Scale bars: A-D: 2um; E & F: 0.5um

Copyright

This image is from Barlow C, Proc Natl Acad Sci U S A 2000 Jan 18;97(2):871-6. Copyright 2000 National Academy of Sciences, U.S.A. J:59933

Associated Alleles

Symbol	Name
Atm^tm1Awb	ataxia telangiectasia mutated; targeted mutation 1, Anthony Wynshaw Boris

Associated Genotypes

Allelic Composition	Genetic Background
Atm^tm1Awb/Atm^tm1Awb	either: 129S6/SvEvTac-Atm^tm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss)