Phenotype Image Detail

Image

Caption

A & B: Electron micrograph panels representing two presumably consecutive phases of microglial activation associated with neuropil loss. Both panels contain a small elongated cell with numerous filiform appendages, a dark cytoplasm with lysosomes (arrow), crenated nucleolemma, and clumpy chromatin including a prominent nucleolus, i.e., features that have been correlated previously with microglia. Putative early stages are associated with vacuolations in the neuropil (stars) into which the filiform appendages of the microglial cells insinuate themselves (A). Presumably later stages are associated with much larger, lacune-like disruptions of the neuropil (B), which may result from the confluence of vacuoles such as those illustrated in A. C and D illustrate unequivocally degenerating neurons whose cytoplasm is severely disrupted, having lost most organelles, including mitochondria and the endoplasmic reticulum. Based on the morphological features of the normal cerebellum, the cell in C may be a Golgi neuron and that in D may be a granule neuron. Asterisks in C and D indicate vacuolations similar to those illustrated in image 1 and 3, which may result from either the degeneration of the processes from the neuron in each panel or from the loss of nearby elements in the neuropil.

Copyright

This image is from Kuljis RO, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12688-93. Copyright 1997 National Academy of Sciences, U.S.A. J:44190

Associated Alleles

Symbol	Name
Atm^tm1Bal	ataxia telangiectasia mutated; targeted mutation 1, David Baltimore

Associated Genotypes

Allelic Composition	Genetic Background
Atm^tm1Bal/Atm^tm1Bal	involves: 129S4/SvJae