Phenotype Image Detail

Image

Caption

Paravalbumin immunohistochemistry of midsagittal cerebellar sections from 5 month old wild type (Upper) and Atm^tm1Fwa/Atm^tm1Fwa (Lower) mice reveals the altered dendritic arborization of Purkinje cells in homozygous mice. C: This can also be observed in Bodian-stained sections from 1 year old mice, wild type (Upper) and homozygous mutant mice (Lower). D: Lucifer-yellow-injected wild type (+/+) and homozygous (y/y)mmutant Purkinje cells dislaying either the prototypic morphology (+/+) or premature dendritic branching (y/y), which can result in multiple dendrites emanating from the soma (Upper y/y cell).

Copyright

This image is from Borghesani PR, Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3336-41. Copyright 2000 National Academy of Sciences, U.S.A. J:61201

Associated Alleles

Symbol	Name
Atm^tm1Fwa	ataxia telangiectasia mutated; targeted mutation 1, Frederick W Alt

Associated Genotypes

Allelic Composition	Genetic Background
Atm^tm1Fwa/Atm^tm1Fwa	involves: 129S4/SvJae * C57BL/6