Phenotype Image Detail

Image

Caption

A: E17.5 wild type diaphragm viewed from the top showing the liver underneath. B: E17.5 Slit3^tm1Dor/Slit3^tm1Dor diaphragm showing a CDH (congenital diaphragmatic hernia) sac containing liver tissue (arrow). C: Sagittal section of a CDH in a P14 homozygous mutant mouse. D-F: Higher magnification views of the boxed areas indicated in C. G: Detection of beta-gal in the lung of an E18.5 homozygous embryo by 5-bromo-4-chloro-3-indolyl beta D-galactoside staining. H: Lung section of a P14 homozygous mouse with CDH. I & J: Lung sections of a 5 week old wild type (I) and homozygous mouse showing pulmonary congestion in the homozygous mouse tissue.

Copyright

This image is from Yuan W, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5217-22. Copyright 2003 National Academy of Sciences, U.S.A. J:83292

Associated Alleles

Symbol	Name
Slit3^tm1Dor	slit guidance ligand 3; targeted mutation 1, David M Ornitz

Associated Genotypes

Allelic Composition	Genetic Background
Slit3^tm1Dor/Slit3^tm1Dor	involves: 129S1/Sv * C57BL/6J