Phenotype Image Detail

Image

Caption

Photomicrographs of sections of mouse eyes from wild type (A, C & E) and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs (B, D and F-I) mice at P3 (A & B), P10 (C & D), and P14 (E & F). Sections stained with H & E (A-F) anti-Ki-67 antibody (G & H), or unrelated primary antibody as a control (I). Note the presence of retrolental tissue (*), pigmented cells within the retrolental tissue in nonalbino mouse (*, F), hyaloid vessels (arrowhead) in the vitreous (A & C) and retrolental tissue (B,D & F), and neuroretina and lens abnormalities (arrows, F). Anterior is to the right. Magnifications: A-F: x40; G: x100; H & I: x400 Scale bars: A: 200um; H: 30um

Copyright

This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215

Associated Alleles

Symbol	Name
Cdkn2a^tm1Cjs	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs	involves: 129X1/SvJ * C57BL/6