Phenotype Image Detail

Image

Caption

A: Schematic diagram of hyaloid vessels in neonatal eye of wild type mouse. B-F: Representative photomicrographs of sections of retrolental mass in albino P10 Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice. Sections were stained with H & E (B) or anti-smooth muscle alpha-actin for pericytes ( C & D) or anti-von Willebrand factor (vWF) for endothelial cells (E) or unrelated primary (F) antibodies. Note the presence of large vascular structures within the retrolental tissue (arrows) and other scattered endothelial cells (arrowheads, E). Magnifications C: x200; B & D-F: x600 Scale bar B & C: 50um

Copyright

This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215

Associated Alleles

Symbol	Name
Cdkn2a^tm1Cjs	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs	involves: 129X1/SvJ * C57BL/6