Phenotype Image Detail

Image

Caption

Histological sections of male (A & B) and female (C & D) gonads are shown, comparing the gonads of wild type (A & C) and Fancl^gcd/Fancl^gcd mice (B & D). The homozygous mouse testis (B) contained groups of normal (N) and abnormal (A) seminferous tubules. The abnormal seminiferous tubules contained only large, vacuolated Sertoli cells. The homozygous mouse ovary (D) is much smaller than the normal ovary (C) and is relatively inactive, containing no developing follicles (F) and only a few, old corpora lutea (C). Also, a well-delineated hemorrhagic cyst is present in the upper-right quadrant of the homozygous ovary (D).

Copyright

This image is from Pellas TC, Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8787-91. Copyright 1991 National Academy of Sciences, U.S.A. J:21254

Associated Alleles

Symbol	Name
Fancl^gcd	Fanconi anemia, complementation group L; germ cell deficient

Associated Genotypes

Allelic Composition	Genetic Background
Fancl^gcd/Fancl^gcd	involves: C57BL/6J * CBA/J