Phenotype Image Detail

Image

Caption

Histological sections of male (A & B) and female (C & D) newborn gonads are shown, comparing the gonads of wild type (A & C) and Fancl^gcd/Fancl^gcd newborn mice. The sex cords (seminiferous tubules) of a normal testis (A) contained large prospermatogonia (P) along with smaller supporting cells (S) situated peripherally along the basement membrane. In contrast, homozygous mouse testis (B) contained both normal and abnormal seminiferous tubules, with the abnormal tubules containing supporting cells only. Similar to the homozygous newborn testis, the homozygous newborn ovary (D) contained mostly supporting cells (S) and fewer oogonia (O) than normal (C).

Copyright

This image is from Pellas TC, Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8787-91. Copyright 1991 National Academy of Sciences, U.S.A. J:21254

Associated Alleles

Symbol	Name
Fancl^gcd	Fanconi anemia, complementation group L; germ cell deficient

Associated Genotypes

Allelic Composition	Genetic Background
Fancl^gcd/Fancl^gcd	involves: C57BL/6J * CBA/J