Phenotype Image Detail

Image

Caption

Representative longitudinal sections through the aortic arch of 25 week old Apoe^tm1Bres/Apoe^tm1Bres (A,C,E & G) and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld (B,D,F & H) mice. The sections shown were cut in the plane of the branch points of the brachiocephalic trunk (BT), left common carotid (LC) and left subclavian (LS). A: Low magnification view of hematoxylin/eosin stained section showing an Apoe homozygous mouse vessel that is largely free of lesions other than a small, but compex, lesion at the entrance into the BT (arrow) and a fibrofatty lesion in the lesser curvature (double arrowheads)> B: Low magnification view of hematoxylin/eosin stained section showing a double homozygous mouse vessel that has extensive foam cell rich lesions that appear to span across the aorta from the lesser curvature to the LS branch point (asterisk). A more complex and highly occlusive lesion is present in the LS (arrow). C: High magnification view to the fibrofatty lesion shown in A. D: High magnification view of the foam cell rich lesion (asterisk) show in B (parallel section). E: High magnification view of the fibrofatty lesion shown in A & C (parallel section) stained with elastic Van Gieson. Note the apparent elastic fiber deposition in intima (arrows). F: High magnification view of the foam cell rich lesion (asterisk) shown in B & D (parallel section) stained with Van Gieson. Note the apparent distortion of the elastic fibers in the medial layer. G: High magnification view of the complex BT lesion shown by arrow in A (parallel sections) stained with Gomori's trichrome. Note the obvious cholesterol clefts (arrows), collagen rich matrix deposition (asterisk), and surface foam cells (arrowheads). H: High magnification view of a complex carotid lesion from a double homozygous mouse with comparable features to those highlighted in G. Scale bars: A & B: 200um; C & D: 100um; E-H: 50um

Copyright

This image is from Xiao Q, Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10335-40. Copyright 1997 National Academy of Sciences, U.S.A. J:42927

Associated Alleles

Symbol	Name
Apoe^tm1Bres	apolipoprotein E; targeted mutation 1, Jan L Breslow
Plg^tm1Jld	plasminogen; targeted mutation 1, Jay L Degen

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss