Phenotype Image Detail

Image

Caption

A: E6.5 control and Smad2^tm1Cxd/Smad2^tm1Cxd embryos. Arrowhead points to the boundary between extraembryonic and embryonic portions of the control embryo. The mutant embryo is round without such a boundary. B: E7.5 embryos. Mutant embryos remain small and do not contain any normal structures such as headfold (hf) and primitive streak (ps). The ectoplacental cone (epc) is normal in the mutants. C & D: E8.5 mutant (C) and control (D) embryos. Note that the mutant enbryos exhibit some variation in size. However, even the largest mutant embryo (right in C) is much smaller than its littermate control (D). Scale bars: A & B: 20um; C & D: 40um

Copyright

This image is from Weinstein M, Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9378-83. Copyright 1998 National Academy of Sciences, U.S.A. J:49084

Associated Alleles

Symbol	Name
Smad2^tm1Cxd	SMAD family member 2; targeted mutation 1, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Smad2^tm1Cxd/Smad2^tm1Cxd	involves: 129S6/SvEvTac * NIH Black Swiss