Phenotype Image Detail

Image

Caption

A & B: Frem1^bat/Frem1^bat mice display cryptophthalmos in adults and embryonic blebs from about 13.5 dpc, which invariably affect the developing eyes (B, arrowheads). C: Sectioning at 16.5 dpc illustrates the formation of a pseudoblepharon (arrowheads), which severely affects development of the underlying eyelids. D: The epidermis (ep) in the blebs of mutant embryos separates from the dermis below the lamina lucida (ll) and the lamina densa (ld) of the basement membrane. The resulting blister cavity (bc) contains residual anchoring fibrils on the subepidermal face.

Copyright

This image is from Smyth I, Proc Natl Acad Sci U S A 2004 Sep 14;101(37):13560-5. Copyright 2004 National Academy of Sciences, U.S.A. J:92613

Associated Alleles

Symbol	Name
Frem1^bat	Fras1 related extracellular matrix protein 1; bat

Associated Genotypes

Allelic Composition	Genetic Background
Frem1^bat/Frem1^bat	C57BL/6J-Frem1^bat