Phenotype Image Detail

Image

Caption

H & E staining of skin sections from 16 week old mice demonstrates that Mapk8^tm1Flv/Mapk8^tm1Flv mice have a thin epidermis, whereas Mapk9^tm1Flv/Mapk9^tm1Flv mice have a thick epidermis, compared with wild type control mice. Immunohistochemical staining for keratin 6 and 10, loricrin, PCNA and p63 indicates abnormal expression in mutant mice. Markedly reduced expression of EGF mRNA in the skin of mutant mice, compared with wild type control, was detected by in situ hybridization.

Copyright

This image is from Weston CR, Proc Natl Acad Sci U S A 2004 Oct 28;101(39):14114-9. Copyright 2004 National Academy of Sciences, U.S.A. J:93433

Associated Alleles

Symbol	Name
Mapk8^tm1Flv	mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell
Mapk9^tm1Flv	mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell

Associated Genotypes

Allelic Composition	Genetic Background
Mapk8^tm1Flv/Mapk8^tm1Flv	B6.129S1-Mapk8^tm1Flv
Mapk9^tm1Flv/Mapk9^tm1Flv	B6.129S2-Mapk9^tm1Flv