Phenotype Image Detail

Image

Caption

A: Lung of Tgfb1^tm1N/Tgfb1^tm1N mouse showing severe phlebitis with perivascular cuffing and interstitial pneumonia. Note arterial wall (arrow) is normal. (H & E; x70) B: Lung from a homozygous mutant mouse showing phlebitis. Inflammatory cells are lymphocytes and macrophages. (H & E; x175) C: Immunohistochemistry for mouse IgG with Bouin's fixed lung from the mutant mouse. Perivascular inflammatory cells include plasma cells (arrows) and lymphocytes. (Hematoxylin; x175) D: Heart of a mutant mouse showing endocarditis and myocarditis. Inflammatory cells are predominantly macrophages (arrows). (H & E; x175) E: Heart of a mutant mouse showing myocarditis and endocarditis. Note lymphocytes and macrophages (arrows) in the lesion. (H & E; x175) F: Myocarditis of the mutant mouse. Mononuclear inflammatory cells include some syncytial cells (arrows). (H & E; x280)

Copyright

This image is from Kulkarni AB, Proc Natl Acad Sci U S A 1993 Jan 15;90(2):770-4. Copyright 1993 National Academy of Sciences, U.S.A. J:50848

Associated Alleles

Symbol	Name
Tgfb1^tm1N	transforming growth factor, beta 1; targeted mutation 1, National Institutes of Health

Associated Genotypes

Allelic Composition	Genetic Background
Tgfb1^tm1N/Tgfb1^tm1N	involves: 129S/SvEv