Phenotype Image Detail

Image

Caption

A & B: Lateral views of ED10.5 Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw (B) and littermate control (A) embryos. Markings are as follows: arrow, abnormal heart morphology; asterisk, swollen pericardial sac; arrowhead, hemorrhage. C & D: Hematoxylin/eosin stained transverse sections of ED10.5 wild type control (C) hearts. Markings are as follows: asterisk, swollen pericardial space; arrowheads, ventricular wall; arrows, sites of septum formation in wild type (but not in double homozygous) embryos. RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle. E & F: PECAM stained ED10.5 double homozygous (F) and control (E) yolk sacs. Arrowheads in F indicate some of the differences in the branching patterns relative to wild type embryos. G & H: PECAM stained ED10.5 double homozygous (H) and control (G) whole embryos. Arrowheads mark the intracranial artery. Scale bars: 100um

Copyright

This image is from An JY, Proc Natl Acad Sci U S A 2006 Apr 18;103(16):6212-7. Copyright 2006 National Academy of Sciences, U.S.A. J:109036

Associated Alleles

Symbol	Name
Ubr1^tm1Avar	ubiquitin protein ligase E3 component n-recognin 1; targeted mutation 1, Alexander Varshavsky
Ubr2^tm1Ytkw	ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1, Yong Tae Kwon

Associated Genotypes

Allelic Composition	Genetic Background
Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw	involves: 129S1/Sv * C57BL/6