Phenotype Image Detail

Image

Caption

Homozygous Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} embryos are smaller than Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ and wild type embryos. Coronal sections of E10.5 wild type (A-D), Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ (E-H) and Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} (I-L) embryos stained with hematoxylin and eosin. Homozygous mutant embryos exhibit reduced thickness of the neuropithelium in the telencephalon (tel), midbrain (mb) and spinal cord (sc). The olfactory pit (op), optic eminence (oe), trigeminal ganglion (Vg) and hindlimbs (hl) are hypoplastic in homozygous mutants. Both heterozygous and homozygous mutants have delayed turning. The homozygous mutant otocyst (ot) is thickened and small. Fag, facio-acoustic VII-VIII preganglion; mp, mandibular prominence; aor, aorta; hrt, heart; rp, Rathke's pouch.

Copyright

This image is from Hurd EA, Mamm Genome 2007 Feb;18(2):94-104 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:119812

Associated Alleles

Symbol	Name
Chd7^Gt(S20-7E1)Sor	chromodomain helicase DNA binding protein 7; gene trap S20-7E1, Philippe Soriano

Associated Genotypes

Allelic Composition	Genetic Background
Chd7^Gt(S20-7E1)Sor/Chd7^Gt(S20-7E1)Sor	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Chd7^Gt(S20-7E1)Sor/Chd7^+	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J