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Caption | A: Hematoxylin/eosin (i-iii) and NADH-TR (iv-vi) stainings of muscle cross sections from Mtm1tm1.1Jman/Y (i,ii,iv & v) and wild type (iii & vi) hindlimbs of 6 week old mice (supero-posterior compartment, magnification x1,000). Note the central (->), peripheral (l) and anarchical (*) accumulation of hematoxylin staining and NADH-TR reactivity that labels mitochondria and endoplasmic reticulum, as compared with the homogeneous pattern of staining in normal muscle. Occasional fiber splitting (<) can be observed in mutant muscle, as reported in centronuclear myopathy. B: Transmission electron micrographs of hindlimb skeletal muscle (biceps cruralis) from mutant mice. Longitudinal section of a muscle fiber (Left, 5 weeks) with a centrally located nucleus and perinuclear accumulation of mitochondria, glycogen, and ER is shown (->). Disorganization of myofibrils and sarcomere disarrays is shown. Dilatations of mitochondria in the micrograph are probably artefactual (magnification, x10,000). Longitudinal section of adjacent myofibers with either normal or degenerative appearance (Right, 13 weeks, x4,000). Myofibrils are highly disorganized and organelles accumulate in the center of fibers (top). | ||||
Copyright | This image is from Buj-Bello A, Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15060-5. Copyright 2002 National Academy of Sciences, U.S.A. J:81791 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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