Phenotype Image Detail

Image

Caption

A: H & E sections of 8 month old female Arhgap1^tm1Yizh/Arhgap1^tm1Yizh or wild type mouse vertebral bodies. The homozygous mouse shows a thin, bowed cortex and thin trabeculae in contrast with the wild type mouse. B: H & E sections of 12 month old female mouse spleens. The mutant mouse shows decreased volume in the white pulp and red pulp of the spleen and smaller lymphoid follicles and decreased red blood cells on the sinusoids of the red pulp. C: H & E staining of 9 month old female mouse dorsal skin sections. In the mutant mouse, the s.c. layer is completely collapsed due to the loss of adipocytes, and the muscle layer shows atrophy at the muscle fibers compared with the wild type mouse. D: Wound healing ability compared in 8 month old female mice. E: H & E staining of a skin wound 4 days after wounding. The wild type shows complete epithelialization of the wound, whereas there is no closure at the wound (indicated by asterisk) in the mutant mouse. Abbreviations: Ep, epidermis; de, dermis; sft, s.c. fat tissue; sm, skeletal muscle.

Copyright

This image is from Wang L, Proc Natl Acad Sci U S A 2007 Jan 23;104(4):1248-53. Copyright 2007 National Academy of Sciences, U.S.A. J:119516

Associated Alleles

Symbol	Name
Arhgap1^tm1Yizh	Rho GTPase activating protein 1; targeted mutation 1, Yi Zheng

Associated Genotypes

Allelic Composition	Genetic Background
Arhgap1^tm1Yizh/Arhgap1^tm1Yizh	involves: 129S6/SvEvTac * C57BL/6