Phenotype Image Detail

Image

Caption

A & B: Vasculature of the developing brain in a wild type littermate (A) and Mapk14^tm1Mms/Mapk14^tm1Mms embryo (B) at 10.5dpc. Note that the tree-like architecture of the major vessels (arrows) connecting to minor branches (arrowheads) in the wild type mouse differs significantly from the relatively uniform size and disorganized pattern of the vasculature in the mutant embryo. C & D: Vasculature of the visceral yolk sac in a wild type littermate (C) and mutant embryo (D). Although the wild type yolk sac displays major vessels (arrows) and branches, the mutant yolk sac has relatively few major vessels with abnormal morphology (arrow), and retains a primitive capillary plexus (small arrows).

Copyright

This image is from Mudgett JS, Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10454-9. Copyright 2000 National Academy of Sciences, U.S.A. J:73417

Associated Alleles

Symbol	Name
Mapk14^tm1Mms	mitogen-activated protein kinase 14; targeted mutation 1, Michael M Shen

Associated Genotypes

Allelic Composition	Genetic Background
Mapk14^tm1Mms/Mapk14^tm1Mms	involves: 129S7/SvEvBrd * C57BL/6