Phenotype Image Detail

Image

Caption

Representative photomicrographs (A-F) of H & E stained sections of eyes from 2 month old Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs (A & D), Trp53^tm1Tyj/Trp53^tm1Tyj (B & E), and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Tyj/Trp53^tm1Tyj (C & F) mice. D-F: Higher magnification of retrolental tissue from corresponding section in A-C. Note the presence of pigmented retrolental tissue ( A & C) and posterior lens capsule destruction and repair ( arrowheads in D & F) in Cdkn2a^tm1Cjs homozygous and double homozygous mouse eyes, whereas minimal retrolental tissue is present (arrow, B) and the posterior lens is intact (E) in the Trp53^tm1Tyj homozygous mouse eye. Neither retrolental tissue nor lens capsule disruption was observed in age-matched wild type mice. Magnifications: A-C: x40; D-F: x400 Scale bar: A: 250um

Copyright

This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215

Associated Alleles

Symbol	Name
Cdkn2a^tm1Cjs	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr
Trp53^tm1Tyj	transformation related protein 53; targeted mutation 1, Tyler Jacks

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs	involves: 129X1/SvJ * C57BL/6
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6