Phenotype Image Detail

Image

Caption

Ultrastructural analysis of skin from wild type (A & B) and Grip1^tm1Paw/Grip1^tm1Paw mice (C & D). In mutant, non blistered areas exhibit a large gap between the epidermis and dermis (C), a feature absent in the skin of littermate controls. Analysis of the roof of the tissue cleft at higher magnification (D) reveals the presence of the lamina densa (LD). This type of lesion is typical of the dystrophic from of EB. Magnifications: A & B, x5,500; C, x44,500; D, x45,000

Copyright

This image is from Bladt F, Proc Natl Acad Sci U S A 2002 May 14;99(10):6816-21. Copyright 2002 National Academy of Sciences, U.S.A. J:79476

Associated Alleles

Symbol	Name
Grip1^tm1Paw	glutamate receptor interacting protein 1; targeted mutation 1, Anthony Pawson

Associated Genotypes

Allelic Composition	Genetic Background
Grip1^tm1Paw/Grip1^tm1Paw	involves: 129X1/SvJ * ICR