Phenotype Image Detail

Image

Caption

A: Large vascular lesion (arrow) visible on the surface of the brain of a 13 month old Ccm2^{Gt(RRG051)Byg}/Ccm2⁺ mouse. B: Sectioning of the lesion reveals a mass of closely packed, tortuous blood vessels. C: Hemorrhaging visible of the surface of the brain of a 37 day old heterozygous mouse. D-F: Vascular malformations consisting of clusters of dilated blood vessels in the brain of a 37 day old mouse. G: Diffuse hemorrhage in the brain of the 37 day old mouse. H: Hemosiderin deposits (blue stain) present in the brain of the 37 day old mouse are indicative of chronic hemorrhaging. (B, D-G) Hematoxylin and eosin staining; (H) Prussian blue stain with nuclear fast red counterstain.

Copyright

This image is from Plummer NW, Mamm Genome 2006 Feb;17(2):119-28 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:105314

Associated Alleles

Symbol	Name
Ccm2^Gt(RRG051)Byg	cerebral cavernous malformation 2; gene trap RRG051, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Ccm2^Gt(RRG051)Byg/Ccm2^+	involves: 129P2/OlaHsd * C57BL/6J