Phenotype Image Detail

Image

Caption

A: Hematoxylin and eosin staining of a normal E10.5 placental labyrinth showing trophoblasts and nucleated erythrocytes in the embryonic vessels and non-nucleated maternal erythrocytes. B: Hematoxylin and eosin staining of a Vhl^tm1Wml/Vhl^tm1Wml E10.5 placental labyrinth lacking embryonal vasculogenesis. Note the presence of embryonic vessels with nucleated erythrocytes on the edge of the thin labyrinth that have not invaded the labyrinth (arrows). C: Hematoxylin and eosin staining of E11.5 mutant mouse placental showing hemorrhage into the abnormal labyrinth. Magnification: A & B: x300; C: x150

Copyright

This image is from Gnarra JR, Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9102-7. Copyright 1997 National Academy of Sciences, U.S.A. J:42486

Associated Alleles

Symbol	Name
Vhl^tm1Wml	von Hippel-Lindau tumor suppressor; targeted mutation 1, W Marston Linehan

Associated Genotypes

Allelic Composition	Genetic Background
Vhl^tm1Wml/Vhl^tm1Wml	involves: 129S4/SvJae * C57BL/6