Phenotype Image Detail

Image

Caption

Morphology of aortic lesions from proxmila aortic roots. Representative section from the aortic root (at the level of the first coronary) showing lesions in a Apoe^tm1Unc/Apoe^tm1Unc mouse at low (x4) (A) and high magnification detail of lower right profile in A (X20). B: Representative section at the aortic root lesion from a Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far mouse at low (x4) (C) and high magnification detail of lower right profile in C (x20). D: Lesions in double homozygous mutant mice show more complex features, including a large necrotic core (NC), numerous needle shaped lucencies indicative of cholesterol crystals (C), and fibrous capping (FC) from smooth muscle cells (stained red). Within the lesion core, greenish blue staining represents proteoglycan, and yellow staining represents collagen.

Copyright

This image is from Terasawa Y, Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13830-4. Copyright 2000 National Academy of Sciences, U.S.A. J:66419

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Ttpa^tm1Far	tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6