Phenotype Image Detail

Image

Caption

A: Two P3 Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0 mice, (M1 & M2), and their normal littermates, showing size variation among the mutants. B: P8 mutant mouse (right) and a normal littermate. Note the sparseness of hair coat and abnormal ears. C-D: Vibrissae of whisker pads are short and oddly angled in a P12 mutant mouse (C), relative to control (D). Note the lack of incisors in the mutant. E: A P17 mutant mouse (right) with its littermate. Its bare forehead, dorsal median line, and abnormal ears are evident. H: Skeletal preparations of normal (left) and mutant (right), showing differences in development of both incisor (I) and molar (M) teeth.

Copyright

This image is from Kuraguchi M, PLoS Genet 2006;2(9):e146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:114152

Associated Alleles

Symbol	Name
Apc^tm2Rak	APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
Tg(KRT14-cre)8Brn	transgene insertion 8, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0	involves: 129/Sv * C57BL/6J * FVB/N * SJL