Phenotype Image Detail

Image

Caption

A-E: P12 normal mouse skin. F-J: P12 Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0 mutant mouse skin. K-N: P12 normal oral cavity. O-R: P12 mutant oral cavity. Stained with hematoxylin and eosin for histology (A,F,K-L,O-P), Ki67 (B,G), B-catenin (C,H,M,Q), K14 (D,I,N,R) and K6 (E,J). Aberrant follicular morphogenesis, characterized by formation of irregularly spaced, nonpolarized hair follicles, in mutant skin is evident. Despite the abnormal histology, proliferation seems to be confined to the hair bulb-like structures (arrow in [G], inset [G' ] at higher magnification), but in mutant skin (arrows in [H], inset [H' ] at higher magnification) and oral cavity (arrows in insets [Q' ] at higher magnification) elevated cytosolic localization of B-catenin is detected in some cells. Scale bars: A-F, H-J 50um; K & O: 250um; G, L-N. P-R: 100um; Q': 20um

Copyright

This image is from Kuraguchi M, PLoS Genet 2006;2(9):e146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:114152

Associated Alleles

Symbol	Name
Apc^tm2Rak	APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
Tg(KRT14-cre)8Brn	transgene insertion 8, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0	involves: 129/Sv * C57BL/6J * FVB/N * SJL