Phenotype Image Detail

Image

Caption

A-D: P3 normal mouse thymus. E-G: Mild P3 Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0 mutant mouse thymus. H-K: Severe P3 mutant mouse thymus. L-O: P13 mutant mouse thymus. Stained with hematoxylin and eosin for histology (A,E,H & L), BrdU (B,I,M), B-catenin (C,F,J & N), and K14 (D,G,K,O). B: Actively dividing thymocytes are visible at the superficial edge of cortex of normal P3 mouse thymus. Note the progression of histological abnormalities in the mutant thymus from mild P3, severe P3 to P13 (A,E,H, L). Scake bars 20um

Copyright

This image is from Kuraguchi M, PLoS Genet 2006;2(9):e146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:114152

Associated Alleles

Symbol	Name
Apc^tm2Rak	APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
Tg(KRT14-cre)8Brn	transgene insertion 8, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0	involves: 129/Sv * C57BL/6J * FVB/N * SJL