Phenotype Image Detail

Image

Caption

A: Light microscopic appearance of representative cerebral cortex of 2 month old Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk mice demonstrates marked vacuolation of the neuropil (arrows) and scattered neuronal perikarya, which are absent in wild type mice (hematoxylin and eosin stained). B: Ultrastructural appearance of typical vacuoles containing membranous debris, denoted by the arrow in the cerebral cortex of a representative homozygous mouse in comparison to a wild type mouse. Scale Bar in A: 50m Magnification in B: 4000x

Copyright

This image is from Leone TC, PLoS Biol 2005 Mar 15;3(4):e101, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:96306

Associated Alleles

Symbol	Name
Ppargc1a^tm1Dpk	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Daniel P Kelly

Associated Genotypes

Allelic Composition	Genetic Background
Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk	involves: 129X1/SvJ * C57BL/6