Phenotype Image Detail

Image

Caption

(E-T) Whole mount skeletons from newborn mice stained with Alcian blue and Alzarin red. (E-L) Forelimbs, (M-T) hindlimbs. (E & M) Wild type, (F & N) Bmp2^tm1Cjt/Bmp2^tm1Cjt Tg(Prrx1-cre)1Cjt/0, (G & O) Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0, (H & P) Bmp7^tm1Rob/Bmp7^tm1Rob, (I & Q) Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4⁺ Tg(Prrx1-cre)1Cjt/0, (J & R) Bmp2^tm1Cjt/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0, (K & S) Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0, (L & T) Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0. Thin red arrow in (F), (I) and (L), defective scapula; thick red arrow in (T), failure of fibula to articulate with knee, and thick black arrow in (L) and (T), missing phalanx in digit III.

Copyright

This image is from Bandyopadhyay A, PLoS Genet 2006 Dec 22;2(12):e216, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:118257

Associated Alleles

Symbol	Name
Bmp2^tm1Cjt	bone morphogenetic protein 2; targeted mutation 1, Clifford J Tabin
Bmp4^tm1Jfm	bone morphogenetic protein 4; targeted mutation 1, James F Martin
Bmp7^tm1Rob	bone morphogenetic protein 7; targeted mutation 1, Elizabeth J Robertson
Tg(Prrx1-cre)1Cjt	transgene insertion 1, Clifford J Tabin

Associated Genotypes

Allelic Composition	Genetic Background
Bmp2^tm1Cjt/Bmp2^+ Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4^+ Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2^tm1Cjt/Bmp2^tm1Cjt Tg(Prrx1-cre)1Cjt/0	involves: C57BL/6 * SJL
Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL