Phenotype Image Detail

Image

Caption

Sections of undecalcified bone were stained with von Kossa and toluidine blue and images captured at original magnifications of x2 (A), x40 (B & C) to evaluate mineralized tissue (A, black) marrow adipocytes (B, white), and the mineralization fronts ( C, yellow and green). The 12 month old Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd bone demonstrated a significant reduction in bone (A) and increase in marrow adipocytes (B) and a decrease in the distance between two consecutive fluorochrome labels (C).

Copyright

This image is from Richard S, PLoS Genet 2005 Dec;1(6):e74, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:115775

Associated Alleles

Symbol	Name
Khdrbs1^tm1Rchd	KH domain containing, RNA binding, signal transduction associated 1; targeted mutation 1, Stephane Richard

Associated Genotypes

Allelic Composition	Genetic Background
Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6