Phenotype Image Detail

Image

Caption

Gross photomicrograph of atrophy in 9 month old Cp^tm1Hrs/Cp^tm1Hrs Heph^sla/Y (Cp-/-Heph-/Y) retina. After removal of the cornea and lens, wild-type eye cup (A) has a transillumination only at the optic nerve. In contrast, the Cp^tm1Hrs/Cp^tm1Hrs Heph^sla/Y (B) has areas of depigmentation (arrows) consistent with retinal pigment epithelium (RPE) pigment loss and atrophy in the peripheral retina.

Copyright

This image is from Hahn P, Proc Natl Acad Sci U S A 2004 Sep 21;101(38):13850-5. Copyright 2004 National Academy of Sciences, U.S.A. J:92620

Associated Alleles

Symbol	Name
Cp^tm1Hrs	ceruloplasmin; targeted mutation 1, Z Leah Harris
Heph^sla	hephaestin; sex-linked anemia

Associated Genotypes

Allelic Composition	Genetic Background
Cp^tm1Hrs/Cp^tm1Hrs Heph^sla/Y	involves: 129X1/SvJ * C57BL/6