Phenotype Image Detail

Image

Caption

Electron micrographs from wild type (A) and Actn4^tm1.1Mrpk/Actn4^tm1.1Mrpk mice (B-D). As shown, homozygous mutant mice were found to have abnormalities that were typically focal, with some areas of podocyte foot process effacement (B), as well as areas that appeared essentially normal (C). Bottom image (D using tannic acid counterstaining) illustrates electron-dense deposits observed in several podocyte cell bodies in mutant mice. No such deposits were observed in wild type or heterozygous mice.

Copyright

This image is from Yao J, PLoS Biol 2004 Jun;2(6):787-94, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:90755

Associated Alleles

Symbol	Name
Actn4^tm1.1Mrpk	actinin alpha 4; targeted mutation 1.1, Martin R Pollak

Associated Genotypes

Allelic Composition	Genetic Background
Actn4^tm1.1Mrpk/Actn4^tm1.1Mrpk	involves: 129S4/SvJae * 129X1/SvJ