Phenotype Image Detail

Image

Caption

Electron micrographs of ependymal cell cilia lining the central portion of the third ventricle (adjacent to the arcuate nucleus of the hypothalamus) in wild type mice ( A & B) and Bbs1^tm1Vcs/Bbs1^tm1Vcs mice (C-F) demonstrate abnormal lengthening of cilia in mutant mice (c & D) and enlargement of the distal region of cilia (E & F). Solid arrows point to intact cilia in mutant mice (C-F). Open-head arrows point to transverse sections of abnormal cilia (C & D). The normal 9 + 2 axonemal arrangement of microtubules in transverse cilia sections from wild type and mutant mice is shown in higher magnification (Inserts of B & D). Abbreviations: BB, basal body; 3V, third ventricle. Scale bars: A-F, 1um

Copyright

This image is from Davis RE, Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19422-7. Copyright 2007 National Academy of Sciences, U.S.A. J:128532

Associated Alleles

Symbol	Name
Bbs1^tm1Vcs	Bardet-Biedl syndrome 1; targeted mutation 1, Val C Sheffield

Associated Genotypes

Allelic Composition	Genetic Background
Bbs1^tm1Vcs/Bbs1^tm1Vcs	involves: 129S1/Sv * 129X1/SvJ