Phenotype Image Detail

Image

Caption

Representative pictures of TUNEL stained retinas of 19 day old wild type, Ercc6^tm1Gvh/Ercc6^tm1Gvh, Xpa^tm1Hvs/Xpa^tm1Hvs, and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Hvs/Xpa^tm1Hvs mice (right panel), 20 hours after exposure of mice to 10Gy of ionizing radiation, and quantification of the number of TUNEL positive cells in the ONL (left panel). Note the significantly higher number of TUNEL positive cells in the retina of double homozygous mice, as compared to wild type and single homozygous mutant littermate controls. Single asterisks indicate statistically significant differences between unirradiated double homozygous and littermate control mice, double asterisks indicate statistically significant differences between unirradiated and irradiated double homozygous mice.

Copyright

This image is from van der Pluijm I, PLoS Biol 2006 Dec 12;5(1):e2, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:122013

Associated Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Hvs/Xpa^tm1Hvs	B6.129P2-Xpa^tm1Hvs Ercc6^tm1Gvh