Phenotype Image Detail

Image

Caption

A: Radiographs of wild type and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Hvs/Xpa^tm1Hvs mice (age as indicated) and photograph of 15 day old double homozygous mouse. B: 2-D images of micro-CT scans of tibiae taken from double homozygous mutant mice and wild type littermate (age indicated in figure). Horizontal sections are shown of the upper and lower part of the tibiae. e, epiphysis; g, growth plate; and d, diaphysis. I indicated the section through the smaller part of the diaphysis, II indicates section through the broader part of the diaphysis. D: Representative footprint patterns of a 19 day old wild type and double homozygous mice. Arrows indicate the trajectory of each mouse. Stride length and front base width measurements of 15 day old wild type and double homozygous mice. The significantly (asterisk; p < 0.001) greather base width in the double mutant mouse indicated ataxia. E: Representative pictures of a TUNEL staining in the retina of wild type and double mutant mice and quantification of the number of TUNEL positive cells. Arrows indicate TUNEL positive cells in the ONL and INL. Note the significantly higher number of TUNEL-positive cells in both the ONL and the INL in the retina of the double mutant mouse compared to the wild type (asterisk; p < 0.05).

Copyright

This image is from van der Pluijm I, PLoS Biol 2006 Dec 12;5(1):e2, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:122013

Associated Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Hvs/Xpa^tm1Hvs	B6.129P2-Xpa^tm1Hvs Ercc6^tm1Gvh