Phenotype Image Detail

Image

Caption

Hindlimbs of newborn wild type mouse (C) and newborn Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0 mouse (D). E & F: Wild type and mutant respectively, showing acridine orange stained hindlimbs of E15.5 mouse embryos. Acridine orange stain is yellow. G & H: Enlarged views of selected regions from (E) and (F), respectively. Black arrows in (G) and (H) show acridine orange stained apoptotic cells in the interdigital mesenchyme, and asterisk in (H) shows the remnant of the apical ectodermal ridge (AER). I & J: Fgf8 mRNA expression in the hindlimbs of #13.5 wild type (I) and mutant (J) embryos. THe thick black arrows in (J) show Fgf8 mRNA expression.

Copyright

This image is from Bandyopadhyay A, PLoS Genet 2006 Dec 22;2(12):e216, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:118257

Associated Alleles

Symbol	Name
Bmp2^tm1Cjt	bone morphogenetic protein 2; targeted mutation 1, Clifford J Tabin
Bmp4^tm1Jfm	bone morphogenetic protein 4; targeted mutation 1, James F Martin
Tg(Prrx1-cre)1Cjt	transgene insertion 1, Clifford J Tabin

Associated Genotypes

Allelic Composition	Genetic Background
Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL