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Phenotype Image Detail
Image
Caption Hematoxylin and eosin stained testis sections showing a normal appearance and organization in the KitMhdasco1/KitMhdasco1, KitWhc1/KitWhc1 and KitMhdasco5/KitMhdasco5 mutants. On the contrary, the seminferous tubules of the KitMhdasow3/KitMhdasow3 adult mutant mouse are lacunar with a complete absence of all the layers coresponding to the differentiation of spermatogonial stem cells. The beta-galactosidase pattern of expression reveals that Kittm1Alf/KitMhdasow3 mutant mice showed no pattern of spermatogenesis compared to Kittm1Alf/+.
Copyright This image is from Magnol L, BMC Dev Biol 2007;7():81, an open-access article, licensee BioMed Central Ltd. J:125831
Associated
Alleles
Symbol Name
KitMhdasco1 KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis spotted coat 1
KitMhdasco5 KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis spotted coat 5
KitMhdasow3 KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis sister of W 3
Kittm1Alf KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Jean-Jacques Panthier
KitWhc1 KIT proto-oncogene receptor tyrosine kinase; white coat
Associated
Genotypes
Allelic Composition Genetic Background
KitMhdasco1/KitMhdasco1 C3HeB/FeJ-KitMhdasco1
KitMhdasco5/KitMhdasco5 C3HeB/FeJ-KitMhdasco5
KitMhdasow3/KitMhdasow3 C3HeB/FeJ-KitMhdasow3
KitWhc1/KitWhc1 involves: C3HeB/Fe * C57BL/6
Kittm1Alf/KitMhdasow3 involves: 129S2/SvPas * C3HeB/FeJ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory