Phenotype Image Detail

Image

Caption

A: E18.5 Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2+ embryos, with only one wild type Pygo2 allele, appear normal. B & C: Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp embryos were smaller, with eye defects including absent or rudimentary lens and folded pigmented retina (arrows). (C) A small percentage of double homozygous embryos display exencephaly.

Copyright

This image is from Schwab KR, BMC Biol 2007;5():15, an open-access article, licensee BioMed Central Ltd. J:121918

Associated Alleles

Symbol	Name
Pygo1^tm1.1Ssp	pygopus 1; targeted mutation 1.1, S Steven Potter
Pygo2^tm1.2Ssp	pygopus 2; targeted mutation 1.2, S Steven Potter

Associated Genotypes

Allelic Composition	Genetic Background
Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss