Phenotype Image Detail

Image

Caption

A: Wax sections of E10.25 wild type and Mapk7^tm1Jsca/Mapk7^tm1Jsca placentas were analyzed by in situ hybridization with an antisense RNA probe against 4311. The spongiotrophoblast layer is indicated by an arrow. B: Wild type and mutant placentas were isolated from E10.25 embryos, paraffin sections taken and then stained with an antibody which recognized cleaved caspase 3. Higher numbers of cleaved caspase 3 positive cells were seen in mutant embryos compared to wild type embryos. In the mutant placentas, apoptosis was seen in endothelial cells (red arrow), trophoblast cells (green arrow) and some embryonic blood cells (yellow arrow) within the labryinth. No apotosis of giant cells was seen.

Copyright

This image is from Yan L, BMC Dev Biol 2003 Dec 16;3():11, an open-access article, licensee BioMed Central Ltd. J:107620

Associated Alleles

Symbol	Name
Mapk7^tm1Jsca	mitogen-activated protein kinase 7; targeted mutation 1, J Simon C Arthur

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Jsca/Mapk7^tm1Jsca	either: (involves: BALB/c) or (involves: C57BL/6)