Phenotype Image Detail

Image

Caption

Transverse coronal sections stained with hematoxylin and eosin. A-C: Serial caudal to cranial sections of wild type embryo showing normal cardiac and vascular anatomy. The left and right ventricles (lv, rv) are seperated by the interventricular septum (ivs). The ascending aorta (a-ao) arises from the left ventricle, continues on as the aortic arch (ao-a), which joins the descending aorta (d-ao). The pulmonary artery (pa) arises from the right ventricle via the pulmonary valve (pv) and continues as the arterial duct (ad), which joins the descending aorta. The left and right atria (la, ra), trachea (tr), right main bronchus (rmb) and esophagus (es) are indicated. D: Section through Jmjd6^tm1Gbf/Jmjd6^tm1Gbf embryo indicating the ventricular septal defect (VSD). E & F: Sections through mutant embryo showing that both aorta and pulmonary artery arise from the right ventricle (double outlet right ventricle), and that the arterial duct of the pulmnary artery is narrow in comparison to the aorta, indicating pulmonary artery hypoplasia. The aortic valve (aov) is indicated. G-I: Serial caudal to cranial sections through mutant embryo showing a VSD, aorta arising from the right ventricle (double outlet right ventricle) and a severely narrowed atrerial duct. Scale bars: 500um axes: r, right; l, left; d, dorsal; v, ventral.

Copyright

This image is from Schneider JE, BMC Dev Biol 2004 Dec 22;4(1):16, an open-access article, licensee BioMed Central Ltd. J:102098

Associated Alleles

Symbol	Name
Jmjd6^tm1Gbf	jumonji domain containing 6; targeted mutation 1, Andreas Lengeling

Associated Genotypes

Allelic Composition	Genetic Background
Jmjd6^tm1Gbf/Jmjd6^tm1Gbf	C57BL/6-Ptdsr^tm1Gbf