Phenotype Image Detail

Image

Caption

Transmission electron micrograph of Crx^tm1Clc/Crx^tm1Clc retina at P21 (A & B), and scanning electron micrograph of mutant outer segment layer (C) at P10. A: Evidence of ciliogenesis in the photoreceptor layer of the mutant mouse retina. Nonmotile connecting cilia were observed in cross section (arrowheads 1,2 and 3). Connecting cilium 1 (arrowhead 1) demonstrated seven microtubule doublets, while cilium 2 and cilium 3 exhibited nine. In A, a displaced cell nucleus (ne) appearing pyknotic and abnormal deposition of matrix (mx) material of unknown identity were seen, along with large amounts of membranous vesicles (arrow) which filled the photoreceptor space and appeared to be released from inner segments. B: Nonmotile connecting cilium in cross section, from a mutant mouse photoreceptor, demonstrating characteristic 9+0 radial array of microtubule doublets. C: Scanning electron micrograph (SEM) of membranous vesicles (arrow shows one example) shed from inner segments of mutant mouse photoreceptors at P10. Figure shows segments viewed from the scleral side with the pigmented epithelium removed. Scale bars: A, 3.7um; B, 88nm; C, 1um

Copyright

This image is from Morrow EM, BMC Neurosci 2005 Jan 27;6(1):5, an open-access article, licensee BioMed Central Ltd. J:95886

Associated Alleles

Symbol	Name
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac