Phenotype Image Detail

Image

Caption

Transmission electron micrographs of the outer plexiform layer (OPL) of Crx^tm1Clc/Crx^tm1Clc retinas at P21. A: Wild type rod spherules contained a single invaginating synapse with one ribbon complex. The spherule was a blunt or club shaped structure. B: Wild type rod terminals contained a single ribbon structure (r). Two processes, from horizontal cells (h), contacted the rod laterally. An additional process, the postsynaptic bipolar dendrite (b), was situated more centrally. Terminals were filled with synaptic vesicles. One coated vesicle originating from the cell membrane was observed (arrow). C: In the OPL of the mutant mouse retinas, photoreceptor terminals appeared highly disorganized. Putative terminals containing synaptic vesicles and ribbon like structures were apparent (arrows), suggesting at least limited generation of synapse components. However, well formed spherules and pedicles were not observed. Further, many terminals appeared to contain multiple ribbon like structures (r). The majority of these ribbons were not associated with the synaptic membrane, but instead were found free floating and, in some instances were perinuclear (D, arrow). Abbreviations: H, horizontal cell; B, bipolar cell; N, nucleus; r, ribbon. Scale bar: A, 500nm; B, 250nm; C & D, 500nm

Copyright

This image is from Morrow EM, BMC Neurosci 2005 Jan 27;6(1):5, an open-access article, licensee BioMed Central Ltd. J:95886

Associated Alleles

Symbol	Name
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac