Phenotype Image Detail

Image

Caption

Embryos were isolated from timed matings of Mapk7^tm1Jsca/⁺ mice and genotyped by PCR analysis of the isolated yolk sac. At 9.5 (A) little difference could be observed between wild type and Mapk7^tm1Jsca/Mapk7^tm1Jsca littermates. At E9.5 (B) difference could be seen between the wild type and homozygous mutant embryos in the head regions, particularly in the cephalic mesenchyme of class II embryos (red arrowhead). At E10.25 (C) homozygous mutant embryos were growth retarded compared to wild type embryos. Mutant embryos showed an abnormal head shape, compared to wild type embryos (green arrow) in class II mutant embryos also showed severe abnormalities in the cephalic mesenchyme and 1^st and 2^nd branchial arches (yellow arrows). Development of the hind limb (star) and lower trunk was also retarded in the mutant embryos.

Copyright

This image is from Yan L, BMC Dev Biol 2003 Dec 16;3():11, an open-access article, licensee BioMed Central Ltd. J:107620

Associated Alleles

Symbol	Name
Mapk7^tm1Jsca	mitogen-activated protein kinase 7; targeted mutation 1, J Simon C Arthur

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Jsca/Mapk7^tm1Jsca	either: (involves: BALB/c) or (involves: C57BL/6)