Phenotype Image Detail

Image

Caption

Scanning electron micrographs of the organ of Corti of P20 and 3 month old wild type (+/+), Myo7a^Hdb/Myo7a⁺ (Hdb/+) and Myo7a^Hdb/Myo7a^Hdb (Hdb/Hdb) mice. Outer hair cells (OHC) in the apical coil form O-shaped stereocilia bundles (B, C & H) rather than the normal V-shaped stereocilia bundles seen in the control (A). Inner hair cells (IHC) stereocilia have fused into giant stereocilia (B arrow, D). The IHC fusion is more extensive in the homozygotes with many more IHCs affected (C). By 3 months, ICH stereocilia fusion is evident in almost all IHCs in the apex in heterozygous mutants (F) and signs of stereocilia fusion are seen in the OHCs (F arrow). In homozygotes, very few IHC and OHC stereocilia remain in the apex (G). Scale bar: G, 10um; D & H, 5um.

Copyright

This image is from Rhodes CR, Mamm Genome 2004 Sep;15(9):686-97 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93998

Associated Alleles

Symbol	Name
Myo7a^Hdb	myosin VIIA; headbanger

Associated Genotypes

Allelic Composition	Genetic Background
Myo7a^Hdb/Myo7a^Hdb	C3HeB/FeJ-Myo7a^Hdb/Ieg
Myo7a^Hdb/Myo7a^+	C3HeB/FeJ-Myo7a^Hdb/Ieg