Phenotype Image Detail

Image

Caption

Scanning electron micrographs taken from wild type (+/+) and Myo7a^Hdb/Myo7a⁺ (Hdb/+) utricles at P20 (A, C) and 5 months (B, D). At P20, heterozygous mutant utricle hair cell stereocilia were very long and thin and lacked the regular height gradation seen in the controls. Type I and type II hair cells were therefore difficult to distinguish as defined in the control example (A). Type I vestibular hair cells have a staircase array of stereocilia with a kinocilium of equal length to the tallest stereocilia. Type II hair cells, by contrast, have a longer kinocilium extending above the tallest stereocilia (+/+, A, B). By 5 months, the rigidity in the stereocilia bundles seen at P20 was absent and the stereocilia bundles were splayed and lay against the utricular surface (D). Scale bar 10um.

Copyright

This image is from Rhodes CR, Mamm Genome 2004 Sep;15(9):686-97 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93998

Associated Alleles

Symbol	Name
Myo7a^Hdb	myosin VIIA; headbanger

Associated Genotypes

Allelic Composition	Genetic Background
Myo7a^Hdb/Myo7a^+	C3HeB/FeJ-Myo7a^Hdb/Ieg