Phenotype Image Detail

Image

Caption

Histological analyses of long bones of control and Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 mice at 15.5 dpc. A,C,E & G are hematoxylin and eosin stained histological sections of controls; and B,D,F & H are Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 mutants. A, B, 15.5 dpc tibiae. C, D, 15.5 dpc femurs. The formation of the primary ossification center (arrows) was delayed in both tibiae and femurs of the mutant in comparison to controls. E, F, 2 week old tibiae, showing development of the secondary ossification center (black arrow) in the control but only chondrocyte hypertrophy (black arrow) in the mutant that also had a disorganized growth plate (red arrow). G, H, 9 month old mutant tibia with little bone marrow (G) filled with adipocytes (H, arrow).

Copyright

This image is from Lee HH, PLoS ONE 2007;2(5):e450, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:129327

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(Wnt4)Bhr	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard R Behringer
Tg(Col2a1-cre)1Bhr	transgene insertion 1, Richard R Behringer

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor^+ Tg(Col2a1-cre)1Bhr/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL