Phenotype Image Detail

Image

Caption

Smarcb1^tm1Gvk/Smarcb1⁺ mice develop head and face tumors. (Left) Tumor present in the soft tissue of the brain penetrating the skull. (Center) Enlarged side of the face because of the presence of tumor mass behind the cheek. (Right) Tumor under the cerebellum has dislodged the eye. B: Immunostain analysis of tumors developed in mutant mice. First row: Paraffin section of normal brain tissue adjacent to tumor HCP01-1103. Second, third and fourth rows represent the immunostain analysis of the paraffin sections of three different mouse tumors (HCP01-1103, HCP02-116 and HCP03-18, respectively) developed in mutant mice. Column 1, hematoxylin and eosin (H & E) staining (a,f,k & p). Colums 2-5 represent immunohistochemical staining using anti INI1 (b,g,l & q), anti-Cyclin D1 (c,h,m & r), anti-smooth muscle actin (SMA) (d,i,n & s); and anti-vimentin (Vim) (e,j,o & t) antibodies, respectively. The arrows point to rhabdoid cells.

Copyright

This image is from Tsikitis M, Proc Natl Acad Sci U S A 2005 Aug 23;102(34):12129-34. Copyright 2005 National Academy of Sciences, U.S.A. J:101185

Associated Alleles

Symbol	Name
Smarcb1^tm1Gvk	SWI/SNF related BAF chromatin remodeling complex subunit B1; targeted mutation 1, Ganjam V Kalpana

Associated Genotypes

Allelic Composition	Genetic Background
Smarcb1^tm1Gvk/Smarcb1^+	involves: 129/Sv * C57BL/6J * SJL/J