Phenotype Image Detail

Image

Caption

A: Autoradiographic localization of hybridization to the ventral marker, HNF3beta. The arrow shows the strong staining in the ventral part of the midbrain in both 12.5 day old wild type (left) and mutant (right) embryos. The square on the top shows a higher magnification of this expression. B: Immunostaining for the general neuronal marker, 3A10, in 11.5 day old wild type and mutant mouse embryos. C: In situ hybridization analysis of Ptx-3 mRNA expression in 11.5 day old mouse embryo. The arrow indicates the positive staining in the ventral midbrain. Wild type and mutant mice showed similar staining. D: Immunohistochemical localization of tyrosine hydroxylase (TH) expression in the ventral midbrain of 12.5 day wild type embryo and lack of expression in the mutant mouse midbrain. Scale bar: 20um

Copyright

This image is from Saucedo-Cardenas O, Proc Natl Acad Sci U S A 1998 Mar 31;95(7):4013-8. Copyright 1998 National Academy of Sciences, U.S.A. J:46856

Associated Alleles

Symbol	Name
Nr4a2^tm1Omc	nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Orla M Conneely

Associated Genotypes

Allelic Composition	Genetic Background
Nr4a2^tm1Omc/Nr4a2^tm1Omc	involves: 129S7/SvEvBrd * C57BL/6
Nr4a2^tm1Omc/Nr4a2^tm1Omc	involves: 129S7/SvEvBrd