Phenotype Image Detail

Image

Caption

Hematoxylin and eosin and Mac-1 immunostaining show numerous foamy cells (a) and ameboid brain macrophages (c) in the thalamic nuclei of 4 month old Hexb^tm1Rlp/Hexb^tm1Rlp mice. In the thalamic nuclei of 4 month old Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice foamy cells were rare (b) and ramified microglia were detected (d) instead of amoeboid brain macrophages. The arrows indicate foamy cells in the homozygous mice, and the arrowheads indicate neurons with storage in both homozygous and double homozygous mice. E & F: Reduction of HRP-labeled cells (arrow) in 4 month old double homozygous mice (f) compared with age matched homozygous mice (e).

Copyright

This image is from Wu YP, Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8425-30. Copyright 2004 National Academy of Sciences, U.S.A. J:90687

Associated Alleles

Symbol	Name
Ccl3^tm1Unc	C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina
Hexb^tm1Rlp	hexosaminidase B; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6