Phenotype Image Detail

Image

Caption

Retina of 120 day old Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn (B) mouse is histologically indistinguishable from a wild type retina (A). Similarly, the retina of the Pde6b^rd1/Pde6b^rd1 Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn (D) is indistinguishable from that of an age matched Pde6b^rd1/Pde6b^rd1 (C) mouse in which essentially the entire outer retina is destroyed and the inner retina remains intact. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; OS, outer segment; Chor, choroid. Note the nearly complete histologic absence of the ONL and OS in C and D.

Copyright

This image is from Selby CP, Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14697-702. Copyright 2000 National Academy of Sciences, U.S.A. J:66580

Associated Alleles

Symbol	Name
Cry1^tm1Asn	cryptochrome circadian regulator 1; targeted mutation 1, Aziz Sancar
Cry2^tm1Asn	cryptochrome circadian regulator 2; targeted mutation 1, Aziz Sancar
Pde6b^rd1	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; retinal degeneration 1

Associated Genotypes

Allelic Composition	Genetic Background
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn Pde6b^rd1/Pde6b^rd1	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Pde6b^rd1/Pde6b^rd1	C3H/HeJ